Enantioselective Terminal Addition to Allenes by Dual Chiral Primary Amine/Palladium Catalysis

Journal: Journal of the American Chemical Society

Published: 2017-03-15

DOI: 10.1021/jacs.7b00437

Affiliations: 3

Authors: 5

Go to article

Research Highlight

Peering at mirror image molecules

© Kristina Peneva/EyeEm /Getty

© Kristina Peneva/EyeEm /Getty

Chinese scientists have developed an efficient method for synthesizing chiral compounds that can be used to build complex molecules, according to a study published in the Journal of the American Chemical Society.

Many biological compounds contain enantiomers — molecules that are mirror images of themselves, whose effects on other biological systems differ — which have been used to enhance the effectiveness of pharmaceutical drugs while minimizing negative side-effects. Synthesizing them, however, is very challenging.

Scientists from China, including researchers from the Collaborative Innovation Center of Chemical Science and Engineering in Tianjin, used a palladium and amine-catalyzed asymmetric alkylation process, which substitutes specific functional groups with other functional groups in compounds, allowing them to rapidly synthesize enantioselective molecules of allene, biologically active compounds that are used to build complex molecules.

The technique is capable of producing high numbers of allene enantiomers, and could also be applied to other biological molecules.

Supported content

  1. J. Am. Chem. Soc. 139, 3631–3634 (2017). doi: 10.1021/jacs.7b00437
Institutions Share
CAS Key Laboratory of Molecular Recognition and Function (LMRF), ICCAS, China 0.33
University of Chinese Academy of Sciences (UCAS), China 0.33
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), China 0.33