Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy

Journal: ACS Nano

Published: 2018-10-16

DOI: 10.1021/acsnano.8b06478

Affiliations: 3

Authors: 9

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Research Highlight

A two-pronged tumour attack

© KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty

© KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty

Nanoparticles developed by researchers in China can deliver a one–two punch to tumours when used in combination with laser light.

Destroying tumours using highly focused light in combination with drugs transported in the bloodstream is an attractive treatment approach for certain cancers. But its effectiveness is reduced by various factors, including limited supply of oxygen.

Now, a team in China that included a researcher from Northwestern Polytechnical University has designed nanoparticles made from direct-acting antiviral molecules that can hurt a tumour in two different ways.

In a mouse model, the team showed that, when activated by the acidic microenvironment of a tumour, the nanoparticles boosted the effectiveness of treatment by laser light. They also attacked the blood vessels that nourish the tumour, limiting the tumour’s ability to grow and spread to other regions.

Supported content

  1. ACS Nano 12, 11446–11457 (2018). doi: 10.1021/acsnano.8b06478
Institutions FC
MOE Key Laboratory of Flexible Electronics (KLOFE), NanjingTech, China 0.78
School of Pharmaceutical Sciences, NanjingTech, China 0.11
Shaanxi Institute of Flexible Electronics (SIFE), NPU, China 0.11

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