Biochemical Gas Sensors (Biosniffers) Using Forward and Reverse Reactions of Secondary Alcohol Dehydrogenase for Breath Isopropanol and Acetone as Potential Volatile Biomarkers of Diabetes Mellitus

Journal: Analytical Chemistry

Published: 2017-11-09

DOI: 10.1021/acs.analchem.7b03191

Affiliations: 9

Authors: 14

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Research Highlight

Electronic sniffers can detect diabetes on the breath

© Julian Ward/Moment/Getty

© Julian Ward/Moment/Getty

An electronic ‘nose’ can pick up the scent of diabetes on human breath, according to a paper published in Analytical Chemistry.

A team of researchers, led by scientists from the Tokyo Medical and Dental University, have developed ‘biosniffers’ that are able to detect traces of two chemicals in human breath, acetone and isopropanol, that are linked to type 1 and type 2 diabetes.

Testing the biosniffers on 55 healthy volunteers, and 25 individuals with either type 2 or type 1 diabetes, they found the devices could detect much higher levels of acetone in the breath of the individuals with diabetes compared to non-diabetic participants. It also found higher levels of isopropanol in people with type 2, but not type 1, diabetes.

The authors said that the biosniffers could offer a non-invasive diagnostic tool for diabetes and other diseases.

Supported content

  1. Analytical Chemistry 89, 12261−12268 (2018). doi: 10.1021/acs.analchem.7b03191
Institutions Share
Department of Preventive Oral Health Care Sciences, TMDU, Japan 0.29
Graduate School of Medical and Dental Sciences, TMDU, Japan 0.21
Department of Educational System in Dentistry, TMDU, Japan 0.19
Department of Biomedical Devices and Instrumentation, TMDU, Japan 0.17
Department of Molecular Endocrinology and Metabolism, TMDU, Japan 0.08
Department of Chemistry and Materials Engineering, Kansai University, Japan 0.04
School of Medicine / Graduate School of Medical Sciences / Faculty of Medical Sciences, Kyushu University, Japan 0.01
Department of Medicine and Bioregulatory Science, Kyushu University, Japan 0.01