Rapid Discrimination of Extracellular Vesicles by Shape Distribution Analysis

Journal: Analytical Chemistry

Published: 2021-04-28

DOI: 10.1021/acs.analchem.1c00258

Affiliations: 7

Authors: 13

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Research Highlight

Speeding up cancer detection

© ANDRZEJ WOJCICKI/Science Photo Library/Getty Images

© ANDRZEJ WOJCICKI/Science Photo Library/Getty Images

Measuring the shapes of globules known as extracellular vesicles (EVs) could offer a rapid, non-invasive way to detect cancer from body-fluid samples and to distinguish between different types of cancer.

Catching cancer early can often make the difference between good and poor treatment outcomes. EVs are highly accessible, being present in body fluids such as urine and blood, making them attractive for cancer screening. But current methods require lengthy processing times to obtain results.

Now, a team that included researchers from Kyushu University in Japan has shown that merely measuring the distribution of shapes of EVs can reveal if cancer is present. The team found that EVs from breast cancer patients and non-cancerous individuals had different shape distributions.

The method could also distinguish between different cancer types. For example, cultured breast cancer cells produced spherical EVs, whereas those from cultured liver cancer cells were a mixture of spherical and oblate particles.

Supported content

  1. Analytical Chemistry 93, 7037−7044 (2021). doi: 10.1021/acs.analchem.1c00258
Institutions Share
Osaka University, Japan 0.38
Kyushu University, Japan 0.23
Nagoya University, Japan 0.23
Institute for Integrated Radiation and Nuclear Science, Kyoto University, Japan 0.08
Tokyo Medical University, Japan 0.08
Japan Science and Technology Agency (JST), Japan 0