Characterization of Antisense Oligonucleotide Impurities by Ion-Pairing Reversed-Phase and Anion Exchange Chromatography Coupled to Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry Using a Versatile Two-Dimensional Liquid Chromatography Setup

Journal: Analytical Chemistry

Published: 2020-03-31

DOI: 10.1021/acs.analchem.0c00114

Affiliations: 1

Authors: 2

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Genentech, Inc., United States of America (USA) 1