Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.

Journal: Cell Stem Cell

Published: 2019-01-03

DOI: 10.1016/j.stem.2018.11.013

Affiliations: 18

Authors: 23

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Research Highlight

Resource competition drives stem cell fate

© Science Photo Library - STEVE GSCHMEISSNER/Getty

© Science Photo Library - STEVE GSCHMEISSNER/Getty

Competition for a limited pool of growth factors determines the fate of stem cells in the testes, a mouse study has found.

A team, which included five scientists from the University of Tsukuba, studied the dynamics of mouse stem cells found in the seminiferous tubules of the male reproductive system.

They discovered that when fibroblast growth factors are limited, the cells tend to go down the path towards differentiated sperm, whereas abundant levels of the signalling protein tend to keep the cells in a state of self-renewal.

The researchers also found that the dosage of growth factor is tightly linked to cell density in the tissue microenvironment of the testes.

Backed by mathematical modelling, the team proposed that competition for resources can explain the regulation of the pool size of stem cells. It remains to be seen whether this holds outside of mouse gonadal tissue.

Supported content

  1. Cell Stem Cell 24, 79–92 (2019). doi: 10.1016/j.stem.2018.11.013
Institutions FC
Division of Germ Cell Biology, NIBB NINS, Japan 0.17
Laboratory Animal Resource Center, University of Tsukuba, Japan 0.11
Department of Stem Cells and Human Disease Models, SUMS, Japan 0.09
Department of Pharmaceutical Biochemistry, Kumamoto University, Japan 0.09
Department of Basic Biology, Sokendai, Japan 0.09
Department of Veterinary Medical Sciences, UTokyo, Japan 0.09
Department of Molecular Embryology, Osaka Women's and Children's Hospital, Japan 0.09
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (LS-TARA Center), University of Tsukuba, Japan 0.04
Division of Environmental Photobiology, NIBB NINS, Japan 0.04
Department of Biological Science and Technology, TUS, Japan 0.04
Wellcome Trust/Cancer Research UK Gurdon Institute (The Gurdon Institute), University of Cambridge, United Kingdom (UK) 0.04
Cavendish Laboratory, University of Cambridge, United Kingdom (UK) 0.04
Department of Anatomy and Embryology, University of Tsukuba, Japan 0.02
Laboratory of Stem Cell Biology and Developmental Immunology, Osaka University, Japan 0.01
Faculty / Graduate School of Medicine, Osaka University, Japan 0.01
WPI Immunology Frontier Research Center (WPI-IFReC), Osaka University, Japan 0.01
Wellcome Trust - MRC Cambridge Stem Cell Institute, University of Cambridge, United Kingdom (UK) 0.01
AMED-CREST, Japan 0

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