Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Journal: Cell Stem Cell

Published: 2018-04-26

DOI: 10.1016/j.stem.2018.04.002

Affiliations: 12

Authors: 17

Go to article

Research Highlight

An unhealthy Spred

© Kay Chernush/Photolibrary/Getty

© Kay Chernush/Photolibrary/Getty

A high-fat diet leads to dysfunction in a master regulatory protein that keeps stem cells working to form new blood.

The protein, known as Spred1, normally prevents the aberrant self-renewal of blood-forming stem cells in the bone marrow. Under normal conditions, Spred1 is not essential for the cells to strike the right balance between replenishment and differentiation. Using mice fed a lard-based diet, the Kanazawa University–led team demonstrated that only under a lifestyle-associated stress, such as consuming a high-fat diet, is Spred1 critical to maintaining the precise regulation of stem cell function.

Without a working copy of Spred1, excessive stem cell proliferation took place, which led to severe anaemia and a form of blood cancer. They thus suggest that drugs designed to boost Spred1 function could help treat leukaemia and other diseases caused by dysregulated blood-forming stem cells.

Supported content

  1. Cell Stem Cell 22, 713–725 (2018). doi: 10.1016/j.stem.2018.04.002
Institutions Share
Cancer Research Institute (CRI), KU, Japan 0.24
WPI Nano Life Science Institute (NanoLSI), KU, Japan 0.18
Division of Stem Cell Therapy, UTokyo, Japan 0.09
Department of Cancer Biology, JFCR, Japan 0.09
Department of Clinical Application, Kyoto University, Japan 0.06
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, China 0.06
Division of Human Pathology, KU, Japan 0.06
Division of Genetics, KU, Japan 0.06
Department of Stem Cell Biology and Medicine, Kyushu University, Japan 0.06
Department of Microbiology and Immunology, Keio University, Japan 0.06
Department of Molecular Microbiology, Osaka University, Japan 0.03
Stanford Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM), United States of America (USA) 0.03