Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation.

Journal: Neuron

Published: 2020-05-20

DOI: 10.1016/j.neuron.2020.05.008

Affiliations: 13

Authors: 26

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Research Highlight

Adult-born neurons strengthen memories during sleep in mice

© KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty

© KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty

Learning-associated neurons that form in the adult mouse brain must get reactivated during rapid eye movement (REM) sleep for new memories to stick.

The fact that dreaming occurs during REM suggests that this stage of sleep may be important for memory processing and consolidation.

Now, a University of Tsukuba–led team has shown that adult-born neurons inside a region of the hippocampus known as the dentate gyrus become activated after a learning experience and that they are then reactivated during the mice’s next phases of REM sleep.

Using optogenetic techniques, the researchers then modulated neuronal activity during REM sleep —. Any perturbation caused the mice to forget their fears, suggesting that these neurons are critical to memory replay and consolidation.

If validated in the human brain, these findings could help scientists develop new treatments for people with memory disorders.

Supported content

  1. Neuron 107, 1–14 (2020) doi: 10.1016/j.neuron.2020.05.008
Institutions Share
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan 0.54
Department of Pediatrics, CU, United States of America (USA) 0.08
Department of Neurophysiology, UTokyo, Japan 0.06
WPI International Research Center for Neurointelligence (WPI-IRCN), UTokyo, Japan 0.06
Department of Genome Biology, University of Tsukuba, Japan 0.04
Graduate School of Information Science and Technology, UTokyo, Japan 0.04
NKI Emotional Brain Institute (EBI), United States of America (USA) 0.04
RIKEN Center for Brain Science (CBS), Japan 0.04
Department of Developmental and Regenerative Biology, Nagoya City University, Japan 0.03
Institute of Brain Science, Nagoya City University, Japan 0.03
Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh, United Kingdom (UK) 0.02
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), The University of Edinburgh, United Kingdom (UK) 0.02
Division of Neural Development and Regeneration, NIPS NINS, Japan 0.01

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