Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

Journal: Molecular Cell

Published: 2017-07-20

DOI: 10.1016/j.molcel.2017.05.023

Affiliations: 7

Authors: 10

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Research Highlight

Circular secrets of the immune response

© Science Photo Library – SCIEPRO/Brand X Pictures/Getty

© Science Photo Library – SCIEPRO/Brand X Pictures/Getty

Genome sequencing has revealed a potential function for circular RNAs in the immune response.

Circular RNAs are a type of RNA — molecules that regulate genetic activity — that has formed in a circle rather than a straight line. Their function in cells is not entirely clear as the closed loop reduces the likelihood of reactions with other molecules.

A team including researchers from the University of Chinese Academy of Sciences used all-human genome sequencing to investigate how circular RNAs form under different conditions. They found that, during viral infections, a drop in the number of two antibodies, the proteins NF90 and NF110, in the nucleus led to a decrease in the number of circular RNA. The team suggest that the two proteins regulate the growth of circular RNA, with which they coordinate a response to viral infections.

Further investigations into the formation and function of circular RNAs may reveal their wider role in immunity.

Supported content

  1. Molecular Cell 67, 214–227 (2017). doi: 10.1016/j.molcel.2017.05.023
Institutions Share
Institute of Biochemistry and Cell Biology (IBCB), SIBS CAS, China 0.33
University of Chinese Academy of Sciences (UCAS), Shanghai, China 0.29
CAS Center for Excellence in Molecular Cell Science, SIBS CAS, China 0.16
CAS-MPG Partner Institute for Computational Biology, China 0.13
ShanghaiTech University, China 0.10