Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.

Journal: Cell Host & Microbe

Published: 2019-04-10

DOI: 10.1016/j.chom.2019.02.015

Affiliations: 4

Authors: 16

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Research Highlight

Gene link found between hepatitis C and diabetes



People with hepatitis C produce higher levels of a liver protein that makes them more susceptible to acquiring type 2 diabetes, researchers at Kanazawa University have shown.

A viral liver infection that can lead to serious liver damage and liver cancer, hepatitis C is a major global health concern, with about 70 million chronic sufferers worldwide.

People infected with the virus have a greater risk of developing type 2 diabetes, but it hasn’t been clear why this is so.

Now, a team at Kanazawa University has found a link between the hepatitis C virus and type 2 diabetes. They discovered that hepatitis C patients express more selenoprotein P, a hepatokine linked to insulin resistance; insulin resistance, in turn, causes type 2 diabetes. Selenoprotein P also inhibits immune responses to the hepatitis C virus.

This finding will help researchers develop medication that targets this link.

Supported content

  1. Cell Host & Microbe 25, 588–601 (2019). doi: 10.1016/j.chom.2019.02.015
Institutions Share
Division of Gastroenterology, KU, Japan 0.41
Division of Endocrinology and Metabolism, KU, Japan 0.31
Division of Health Sciences, KU, Japan 0.22
Public Central Hospital of Matto Ishikawa, Japan 0.06