Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.

Journal: Cell Host & Microbe

Published: 2019-04-10

DOI: 10.1016/j.chom.2019.02.015

Affiliations: 4

Authors: 16

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Research Highlight

Gene link found between hepatitis C and diabetes



People with hepatitis C produce higher levels of a liver protein that makes them more susceptible to acquiring type 2 diabetes, researchers at Kanazawa University have shown.

A viral liver infection that can lead to serious liver damage and liver cancer, hepatitis C is a major global health concern, with about 70 million chronic sufferers worldwide.

People infected with the virus have a greater risk of developing type 2 diabetes, but it hasn’t been clear why this is so.

Now, a team at Kanazawa University has found a link between the hepatitis C virus and type 2 diabetes. They discovered that hepatitis C patients express more selenoprotein P, a hepatokine linked to insulin resistance; insulin resistance, in turn, causes type 2 diabetes. Selenoprotein P also inhibits immune responses to the hepatitis C virus.

This finding will help researchers develop medication that targets this link.

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  1. Cell Host & Microbe 25, 588–601 (2019). doi: 10.1016/j.chom.2019.02.015
Institutions Share
Kanazawa University (KU), Japan 0.94
Public Central Hospital of Matto Ishikawa, Japan 0.06