The piRNA Response to Retroviral Invasion of the Koala Genome.

Journal: Cell

Published: 2019-09-23

DOI: 10.1016/j.cell.2019.09.002

Affiliations: 6

Authors: 9

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Research Highlight

Koalas mount genetic immune response to virus

© Photo by Bobby-Jo Clow/Getty

© Photo by Bobby-Jo Clow/Getty

The koala genome is fighting back against a virus that is currently sweeping through wild koala populations, leaving the animals susceptible to infections and certain cancers.

A study co-led by University of Queensland scientists shows how small RNA molecules called piRNAs encoded in the koala genome mount sequential immune responses to the virus.

In germ cells, which give rise to eggs and sperm, these piRNAs first have a way of keeping viral invaders from taking up residency in the host DNA.

The system isn’t perfect though, and some viruses do sneak into the genome. So the piRNAs then mount a second line of defense in which they quash the activity of established viral parasites.

The finding could help scientists develop new strategies for combating this and other viral diseases. The study also sheds light on evolution in action, since past viral infections have shaped the genomes of all animals, including humans.

Supported content

  1. Cell 179, 632–643 (2019). doi: 10.1016/j.cell.2019.09.002
Institutions Share
Program in Molecular Medicine (PMM), UMass Medical School, United States of America (USA) 0.44
School of Agriculture and Food Sciences, UQ, Australia 0.22
School of Chemistry and Molecular Biosciences (SCMB), UQ, Australia 0.11
Clinical Translational Research Center at Shanghai Pulmonary Hospital, Tongji University, China 0.07
School of Life Sciences and Technology, Tongji University, China 0.07
Program in Bioinformatics and Integrative Biology (BIB), UMass Medical School, United States of America (USA) 0.07

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