Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Journal: Cell

Published: 2018-11-15

DOI: 10.1016/j.cell.2018.10.015

Affiliations: 10

Authors: 15

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Research Highlight

Brown fat linked to satiety cues

© Planet Flem/Getty

© Planet Flem/Getty

Brown fat does more than just turn food into body heat. According to a study led by scientists at the Technical University of Munich, this ‘good’ fat also interacts with a gut hormone to tell the brain when to stop eating.

The study revealed a previously unknown connection between the gut, the brain and brown fat tissue — a finding that could lead to new treatments for obesity and diabetes.

The researchers injected hungry mice with secretin, a hormone normally released during meals to stimulate the secretion of digestive enzymes. The hormone both suppressed the animals’ appetites and increased their heat production — but only when brown tissue was active, highlighting the importance of the fat in causing the feeling of satiety.

In human volunteers, higher levels of secretin in the blood also corresponded to more metabolically active brown fat.

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  1. Cell 175, 1561–1574.e12 (2018). doi: 10.1016/j.cell.2018.10.016
Institutions FC
Cluster of Excellence - Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), UoC, Germany 0.17
Center for Molecular Medicine Cologne (CMMC), UoC, Germany 0.17
Institute for Genetics, UoC, Germany 0.14
Department of Pharmacology, UI, United States of America (USA) 0.13
Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), UoC, Germany 0.13
Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Germany 0.11
Max Planck Institute for Heart and Lung Research (MPI-HLR), Germany 0.07
Max Planck Institute for Biology of Ageing (MPIAGE), Germany 0.03
Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Germany 0.02
German Center for Diabetes Research (DZD), Germany 0.01

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