Ancestral Origins and Genetic History of Tibetan Highlanders

Journal: American Journal of Human Genetics

Published: 2016-09-01

DOI: 10.1016/j.ajhg.2016.07.002

Affiliations: 9

Authors: 20

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Research Highlight

Genetic portrait of Tibetans’ complex ancestry

© hadynyah/E+/Getty

© hadynyah/E+/Getty

The ancestors of modern Tibetans colonized the freezing, high-altitude Tibetan Plateau up to 62,000 years ago, and even survived an ice age there.

An international team of researchers, including scientists from the University of Chinese Academy of Sciences, analyzed the genomes of 38 Tibetan highlanders and 39 Han Chinese lowlanders to solve a long-standing puzzle about the ancestry of modern Tibetans.

They found that around 6 per cent of Tibetan genetic material can be traced to Paleolithic and Neolithic early humans — Denisovans, Neanderthals and other unknown hominins — who mingled on the Tibetan Plateau 62,000–38,000 years ago, before the Last Glacial Maximum. The remaining 94 per cent is made up of modern contributions from East, Central and South Asia, western Eurasia and Oceania.

While this ‘human melting pot’ existed in Tibet long before the last Ice Age, the reason these prehistoric groups were drawn to such an inhospitable region remains a mystery.

Supported content

  1. The American Journal of Human Genetics 99, 580–594 (2016). doi: 10.1016/j.ajhg.2016.07.002
Institutions Share
CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, China 0.33
University of Chinese Academy of Sciences (UCAS), China 0.23
State Key Laboratory of Genetic Engineering, Fudan University, China 0.13
MOE Key Laboratory of Contemporary Anthropology (KLCA), Fudan University, China 0.13
Xinjiang Medical University (XJMU), China 0.05
State Key Laboratory of Genetic Resources and Evolution, KIZ CAS, China 0.05
School of Medicine, Xizang Minzu University, China 0.05
School of Life Science and Technology (SLST), ShanghaiTech, China 0.03
Collaborative Innovation Center for Genetics and Development, Fudan University, China 0.01