Data-Driven Identification of Hydrogen Sulfide Scavengers

Journal: Angewandte Chemie International Edition

Published: 2019-08-05

DOI: 10.1002/anie.201905580

Affiliations: 6

Authors: 11

Go to article

Research Highlight

Making sense of hydrogen sulfide signalling

© lvcandy/Getty

© lvcandy/Getty

Fluorescent sensor molecules that detect hydrogen sulfide (H2S), a key biological signalling molecule, could form the basis of a new class of hydrogen sulfide–scavenging drugs.

The dysregulation of hydrogen sulfide levels in cells has been implicated in health conditions from cancer to diabetes. To combat the effects of excess hydrogen sulfide production, compounds are needed to curb its production, but they have proved hard to create.

Now, a team that included researchers from Tohoku University Graduate School of Medicine has taken a data-driven approach to develop compounds that lower hydrogen sulfide concentration. Rather than try to inhibit hydrogen sulfide production, they have developed scavenger molecules that can mop up hydrogen sulfide in biological environments.

The team designed the scavengers by analysing an existing range of fluorescent sensor molecules for hydrogen sulfide, which strongly and selectively bind hydrogen sulfide. A series of molecules based on sulfonyl azide–based sensors demonstrated promising hydrogen sulfide scavenging performance in cellular environments.

Supported content

  1. Angewandte Chemie 58, 10898–10902 (2019). doi: 10.1002/anie.201905580
Institutions Share
WSU Department of Chemistry, United States of America (USA) 0.45
Department of Anesthesia, Critical Care and Pain Medicine, MGH, United States of America (USA) 0.18
Department of Environmental Medicine and Molecular Toxicology, Tohoku University, Japan 0.18
Affiliated Cancer Hospital of Guangzhou Medical University, China 0.06
Cancer Research Institute, GMU, China 0.06
Key Laboratory of Protein Modification and Degradation, GMU, China 0.06

Return