Few-Layer Graphdiyne Nanosheets Applied for Multiplexed Real-Time DNA Detection

Journal: Advanced Materials

Published: 2017-03-01

DOI: 10.1002/adma.201606755

Affiliations: 9

Authors: 14

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Research Highlight

Directly detecting DNA with graphdiyne

© Ralf Hiemisch/Getty

© Ralf Hiemisch/Getty

A fluorescence detector made from graphdiyne – a relative of graphene – is paving the way to prompt, precise DNA detection.

Fluorescence sensors detect DNA using molecular ‘probes’ labelled with different coloured dyes that glow, or fluoresce when they interact with a target DNA. However, rapid detection of specific DNA sequences without background noise is still tricky.

A team including researchers from Nanjing Tech University created a fluorescence sensor with just a few sheets of graphdiyne, selected for its excellent molecular adsorption properties. Like graphene, graphdiyne is a single layer of carbon atoms in hexagonal rings, but is further divided into triangular pores by chains of carbon-hydrogen bonds. The graphdiyne sensor was quicker to detect DNA than a graphene-based sensor, and could distinguish between a range of target single and double-strand DNA from viruses.

Biosensors such as these, that can rapidly detect distinct DNA, could be used for immediate disease diagnosis, gene therapy and food safety checks.

Supported content

  1. Advanced Materials 29, 1606755 (2017). doi: 10.1002/adma.201606755
Institutions Share
University of Science and Technology Beijing (USTB), China 0.14
Nanjing Tech University (NanjingTech), China 0.14
Nanjing University of Posts and Telecommunications (NUPT), China 0.14
Institute of Chemistry (ICCAS), CAS, China 0.14
State Key Laboratory of Biochemical Engineering, IPE CAS, China 0.10
CAS Center for Excellence in Nanoscience, NCNST CAS, China 0.10
Griffith University, Australia 0.10
Nanyang Technological University (NTU), Singapore 0.07
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), China 0.07